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| 品牌 | absin | CAS | 3943-74-6 |
|---|---|---|---|
| 分子式 | C9H10O4 | 纯度 | ＞98% |
| 分子量 | 182.17 | 货号 | abs47028160 |
| 规格 | 25mg | 供货周期 | 现货 |
| 主要用途 | increase bone mass in growing or ovariec | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Methyl Vanillate 3943-74-6
| 产品描述 | |
| 描述 | Hovenia dulcis Thunb extract and its ingredient methyl vanillate activate Wnt/β-catenin pathway and increase bone mass in growing or ovariectomized mice. |
| 纯度 | ＞98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 香草酸甲酯 |
| 外观 | Pale yellow to beige Powder |
| 可溶性/溶解性 | DMSO : ≥ 100 mg/mL (548.94 mM) |
| 生物活性 | |
| 靶点 | Wnt/β-catenin |
| In vitro(体外研究) | Methyl vanillate (MV) activates the Wnt/β-catenin pathway and induces osteoblast differentiation in vitro. It increases the expression of differentiation markers RUNX2, BMP2, ALP, and OCN in a dose-dependent manner. MV decreases and increases the expression of RANKL and OPG, respectively. Methyl vanillate dose-dependently elevates ALP activity in calvarial osteoblasts. |
| In vivo(体内研究) | Methyl vanillate rescues trabecular or cortical femoral bone loss in the ovariectomized mice without inducing any significant weight changes or abnormality in liver tissue when administrated orally. |
| 参考文献 | |
| 参考文献 |
| 研究领域 | |
| 研究领域 | Immunology CancerCancer Metabolism CancerTumor biomarkers CancerTumor immunology Stem CellsCancer Stem Cells Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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