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| 品牌 | absin | CAS | 38183-03-8 |
|---|---|---|---|
| 分子式 | C15H10O4 | 纯度 | ≥98% |
| 分子量 | 254.24 | 货号 | abs47028159 |
| 规格 | 25mg | 供货周期 | 现货 |
| 主要用途 | is a naturally-occurring flavone | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
7,8-Dihydroxyflavone 38183-03-8
| 产品描述 | |
| 描述 | 7,8-Dihydroxyflavone (7,8-DHF) is a naturally-occurring flavone found in Godmania aesculifolia, Tridax procumbens, and primula tree leaves. |
| 纯度 | ≥98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 7,8-二羟基黄酮 |
| 外观 | 白色结晶性粉末 |
| 可溶性/溶解性 | DMSO : 47 mg/mL (184.9 mM) Ethanol : 1 mg/mL (3.93 mM) |
| 生物活性 | |
| 靶点 | TrkB receptor |
| In vitro(体外研究) | 7,8-DHF is one of the positive compounds that specifically activate TrkB, but not TrkA or TrkC, at a concentration of 250 nM. In addition to cortical and hippocampal neurons, 7,8-DHF also protects other cell types including the RGC (retinal ganglion cells) and PC12 cells from excitotoxic and oxidative stress-induced apoptosis and cell death. Thus, it has neuroprotective properties. |
| In vivo(体内研究) | 7,8-Dihydroxyflavone is a bioavailable chemical that can pass through the BBB to provoke TrkB and its downstream PI3K/Akt and MAPK activation in mouse brain upon intraperitoneal or oral administration. 7,8-DHF promotes the survival and reduces apoptosis in cortical neurons of traumatic brain injury as administration of 7,8-DHF at 3 h post-injury reduces brain tissue damage via the PI3K/Akt pathway. Its treatment does not induce any apparent toxicity in mice and is not toxic to the mice during the chronic treatment. 7,8-DHF displays robust therapeutic efficacy toward Alzheimer's disease and inhibits obesity through activating muscular TrkB. |
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| 研究领域 | |
| 研究领域 | CancerOncoproteins/suppressorsOncoproteinsGrowth factor receptors Cell CycleCell differentiation Developmental BiologyOrganogenesisNervous system development MetabolismPathways and ProcessesMetabolism processesCellular metabolism NeuroscienceDevelopment NeuroscienceNeurology processNeurogenesis NeuroscienceNeurology processGrowth and DevelopmentNeurotrophins NeuroscienceNeurotransmissionIntracellular SignalingKinases Signal TransductionProtein PhosphorylationTyrosine KinasesReceptor Tyrosine Kinases Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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