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| 品牌 | absin | CAS | 1276110-06-5 |
|---|---|---|---|
| 分子式 | C21H18N4O4S | 纯度 | ＞98% |
| 分子量 | 422.46 | 货号 | abs47027988 |
| 规格 | 10mg | 供货周期 | 现货 |
| 主要用途 | is a potent inhibitor of PI3Kα | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
HS-173 1276110-06-5
| 产品描述 | |
| 描述 | HS-173 is a potent inhibitor of PI3Kα with IC50 value of 0.8 nM. |
| 纯度 | ＞98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | HS 173；HS173 |
| 外观 | Grey to Brown Powder |
| 可溶性/溶解性 | DMSO : 78 mg/mL (184.6 mM) |
| 生物活性 | |
| 靶点 | PI3Kα |
| In vitro(体外研究) | HS-173 shows potent antiproliferative effects in T47D, SK-BR3, and MCF7 cells with IC50 of 0.6, 1.5, and 7.8 μM, respectively. HS-173 causes complete suppression of the PI3K pathway in cancer cell lines (Hep3B and SkBr3). Moreover, HS-173 induces cell apoptosis by affecting cell-cycle distribution and activating caspases, and block VEGF-induced angiogenesis in vitro. Combined treatment with Sorafenib and HS-173 has a synergistic anti-cancer effect on pancreatic cancer cells. |
| In vivo(体内研究) | HS-173 diminishes blood vessel formation in mice. HS-173 markedly attenuates the development of liver fibrosis by blocking PI3K/Akt signaling in vivo. |
| 研究领域 | |
| 研究领域 | Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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