GHF-5074 749269-83-8

简要描述：GHF-5074 749269-83-8
CHF5074 is a novel γ-secretase modulator, reduces Aβ42 and Aβ40 secretion, with an IC50 of 3.6 and 18.4 μM, respectively.

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品牌	absin	CAS	749269-83-8
分子式	C16H11Cl2FO2	纯度	99%
分子量	325.162	货号	abs47027967
规格	2mg	供货周期	现货
主要用途	is a novel γ-secretase modulator	应用领域	化工,生物产业,农林牧渔,制药/生物制药,综合

GHF-5074 749269-83-8

产品描述
描述	CHF5074 is a novel γ-secretase modulator, reduces Aβ42 and Aβ40 secretion, with an IC50 of 3.6 and 18.4 μM, respectively.
纯度	99%
储存/保存方法	Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
可溶性/溶解性	10 mM in DMSO
生物活性
靶点	γ secretase
In vitro(体外研究)	In human neuroglioma cells over-expressing the Swedish mutated APP , CHF5074 preferentially lowers Aβ42 secretion with an IC50 of 3.6 µmol/L. CHF5074 does not display inhibitory activity on COX-1 and COX-2 enzymes when employed at concentrations up to 100 µmol/L and 300 µmol/L respectively.
In vivo(体内研究)	In rats, CHF5074 is orally well absorbed (50%) and is slowly eliminated from plasma (t1/2 ≈ 20 h). In Tg2576 transgenic mice, chronic treatment with CHF5074 markedly reduces brain Aβ burden without histological signs of peripheral Notch-mediated toxicity.
参考文献
参考文献	1. Imbimbo BP, et al. J Pharmacol Exp Ther. 2007 Dec;323(3):822-30. 2. Ronsisvalle N, et al. Curr Alzheimer Res. 2014;11(7):714-24.

研究领域
研究领域	Drug DiscoverySmall Molecule DrugLead Compound Discovery

GHF-5074 749269-83-8温馨提示：本产品仅作科研实验使用，不支持临床等研究

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