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| 品牌 | absin | CAS | 747413-08-7 |
|---|---|---|---|
| 分子式 | C19H17ClN2O5 | 纯度 | 99% |
| 分子量 | 388.802 | 货号 | abs47027966 |
| 规格 | 10mg | 供货周期 | 现货 |
| 主要用途 | is a potent HSP90 inhibitor | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
VER-50589 747413-08-7
| 产品描述 | |
| 描述 | VER-50589 is a potent HSP90 inhibitor with IC50 of 21 nM for HSP90β. |
| 纯度 | 99% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 可溶性/溶解性 | 200 mM in DMSO and ethanol |
| 生物活性 | |
| 靶点 | HSP90β |
| In vitro(体外研究) | VER-50589 inhibits the intrinsic ATPase activity of recombinant yeast Hsp90 with IC50 of 143 nM, and produces antiproliferative activity in a panel of human cancer cell lines and nontumorigenic cells in vitro. VER-50589 causes induction of HSP72 and HSP27 alongside depletion of client proteins, including C-RAF, B-RAF, and survivin, and the protein arginine methyltransferase PRMT5, which further result in cell cycle arrest and apoptosis. |
| In vivo(体内研究) | In HCT116 human colon cancer xenografts, VER-50589 (100 mg/kg i.p.) results in a statistically significant reduction of ∼30% in tumor volume and weight, as well as induction of HSP72 and depletion of ERBB2 and C-RAF. |
| 研究领域 | |
| 研究领域 | Signal TransductionMetabolism Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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