Rosuvastatin 287714-41-4

简要描述：Rosuvastatin 287714-41-4
Rosuvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase.

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Rosuvastatin 287714-41-4

产品描述
描述	Rosuvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reducuase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Rosuvastatin belongs to a class of medications called statins and is used to reduce plasma cholesterol levels and prevent cardiovascular disease.
纯度	98%
储存/保存方法	Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
别名	瑞shu伐他汀；罗伐他汀 ; ZD 4522
外观	White to light yellow powder
可溶性/溶解性	DMSO ：≥50mg/ml
生物活性
靶点	HMG-CoA reductase
In vitro(体外研究)	Rosuvastatin possesses a greater number of binding interactions with HMG-CoA reductase and has a high affinity for the active site of the enzyme. Rosuvastatin is relatively hydrophilic and is selectively taken up by, and active in, hepatic cells. Rosuvastatin has the longest terminal half-life of the statins and is only minimally metabolized by the cytochrome P450 (CYP 450) enzyme system with no significant involvement of the 3A4 enzyme.
In vivo(体内研究)	Rosuvastatin attenuates arterial thrombosis and neointima formation, and it may stabilise vascular lesions developing after endothelial injury in mice. These effects are independent of systemic lipid lowering.
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研究领域

CancerCancer MetabolismMetabolic signaling pathwayMetabolism of lipids and lipoproteins

CardiovascularAtherosclerosisLipoprotein metabolism

CardiovascularLipids / LipoproteinsLipid MetabolismCholesterol Metabolism

MetabolismTypes of diseaseHeart disease

MetabolismPathways and ProcessesMetabolic signaling pathwaysLipid and lipoprotein metabolismCholesterol Metabolism

MetabolismPathways and ProcessesMetabolic signaling pathwaysLipid and lipoprotein metabolismLipid metabolism

MetabolismPathways and ProcessesMetabolic signaling pathwaysLipid and lipoprotein metabolismLipoprotein metabolism

Signal TransductionMetabolismLipid metabolism

Drug DiscoverySmall Molecule DrugLead Compound Discovery

Rosuvastatin 287714-41-4温馨提示：本产品仅作科研实验使用，不支持临床等研究

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