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| 品牌 | absin | CAS | 51-45-6 |
|---|---|---|---|
| 分子式 | C5H9N3 | 纯度 | ≥98% |
| 分子量 | 111.15 | 货号 | abs47027417 |
| 规格 | 10mg | 供货周期 | 现货 |
| 主要用途 | is an organic nitrogenous | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Histamine 51-45-6
| 产品描述 | |
| 描述 | Histamine is an organic nitrogenous compound involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter. |
| 纯度 | ≥98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 组胺；Ergamine |
| 外观 | 白色或淡黄色结晶粉末 |
| 可溶性/溶解性 | Ethanol : Soluble Water : ≥34 mg/mL |
| 生物活性 | |
| 靶点 | Histamine Receptor |
| In vitro(体外研究) | Histamine stimulates the proliferation of human articular chondrocytes in culture. Histamine is reported to modify the behaviour of many cell types in vitro, including chondrocytes, fibroblasts, macrophages, epithelial cells, endothelial cells, and T cells. Histamine also modulates the production of many cytokines and the expression of their receptors. Histamine regulates cellular processes through the expression of histamine receptors. Histamine stimulates the production of matrix metalloproteinases (MMPs)-13 and -3 (collagenase 3 and stromelysin-1, respectively) by histidine decarboxylase (HAC) in vitro. |
| In vivo(体内研究) | Histamine has a recognised role in allergic and inflammatory reactions and is an important modulator of numerous physiological processes, including cell proliferation, angiogenesis, and vasopermeability. Histamine dilates vasculature, increases blood flow, while it induces hyperpermeability in venula. It disrupts endothelial barrier formation of venula indicated by changes in vascular endothelial cadherin (VE-cadherin) localization at endothelial cell junction. |
| 参考文献 | |
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| 研究领域 | |
| 研究领域 | Immunology Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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