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| 品牌 | absin | CAS | 50-91-9 |
|---|---|---|---|
| 分子式 | C9H11FN2O5 | 纯度 | 99% |
| 分子量 | 246.19 | 货号 | abs47027416 |
| 规格 | 25mg | 供货周期 | 现货 |
| 主要用途 | is an oncology drug that belongs to the | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Floxuridine 50-91-9
| 产品描述 | |
| 描述 | Floxuridine (5-fluorodeoxyuridine) is an oncology drug that belongs to the class known as antimetabolites with an GI50 of 5.1 μM for the inhibition of PEPT1. |
| 纯度 | 99% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 5-氟-2'-脱氧脲核苷；氟尿苷;5-Fluoro-2'-deoxyuridine |
| 外观 | White to almost white Powder |
| 可溶性/溶解性 | DMSO : 125 mg/mL (507.74 mM; Need ultrasonic) H2O : ≥ 50 mg/mL (203.10 mM) |
| 生物活性 | |
| 靶点 | DNA/RNA Synthesis |
| In vitro(体外研究) | Floxuridine exhibits higher affinity for PEPT1 than the corresponding 5'-O-mono amino acid ester prodrugs. Floxuridine combined with Leucovorin results in synergistic inhibitory effects on growth of human T-lymphoblast leukemia cells. Floxuridine significantly inhibits the uptake of both -inosine and -adenosine (60-70% of control), while its amino acid ester prodrugs including Val, Phe, Pro, Asp, and Lys esters exhibits markedly decreased inhibition potency (10-30% of control). Floxuridine inhibits cell proliferation by more than 50% relative to the untreated control cells at 36 days, the cell numbers still increases fourfold compared with the initial cell density. Floxuridine results in prolonged effects on the proliferation of human Tenon's capsule fibroblasts in vitro. Floxuridine (FUDR) is an ideal drug for hepatic arterial infusion (HAI) due to its short half life, steep dose response curve, high total body clearance, and high hepatic extraction. |
| 参考文献 | |
| 参考文献 |
| 研究领域 | |
| 研究领域 | CancerTumor biomarkers CancerTumor immunology MetabolismTypes of disease Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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