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| 品牌 | absin | CAS | 145-13-1 |
|---|---|---|---|
| 分子式 | C21H32O2 | 纯度 | ＞98% |
| 分子量 | 316.48 | 货号 | abs47027341 |
| 规格 | 50mg | 供货周期 | 现货 |
| 主要用途 | found in steroid hormone-producing tissu | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Pregnenolone 145-13-1
| 产品描述 | |
| 描述 | A 21-carbon steroid, derived from CHOLESTEROL and found in steroid hormone-producing tissues. Pregnenolone is the precursor to GONADAL STEROID HORMONES and the adrenal CORTICOSTEROIDS. |
| 纯度 | ＞98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 孕烯醇酮；3β-Hydroxy-5-pregnen-20-one |
| 外观 | White to off-white Powder |
| 可溶性/溶解性 | DMSO : 12.5 mg/mL (39.50 mM; Need ultrasonic) |
| 生物活性 | |
| 靶点 | progestogen Receptor |
| In vitro(体外研究) | Pregnenolone induces a large, dose-related increase of both the rate and extent of MAP2-induced tubulin assembly, whereas progesterone, inactive per se, counteracted the stimulatory effect of Pregnenolone. Pregnenolone-increased assembly of microtubules produces a completely normal structure. Pregnenolone preserves microtubule abundance and promotes cell movement during epiboly. Pregnenolone results in dramatic reduction in GR nuclear localization in mouse hippocampal cell line (HT-22). Pregnenolone has neuroprotective effects against both glutamate and amyloid beta protein neuropathology. |
| In vivo(体内研究) | Pregnenolone sustains its proliferative activity in vivo and stimulates the growth of LNCaP-tumor xenografts in intact male SCID mice as well as in castrated animals. Pregnenolone is shown to activate transcription through the LNCaP androgen receptor (AR), but not the wild-type AR. Pregnenolone results in a significant decrease in the accumulation of astrocytes in the proximity of the wound and in a decreased bromodeoxyuridine incorporation in reactive astrocytes of rats. Pregnenolone administration results in elevations in downstream neurosteroids such as allopregnanolone, a molecule with neuroprotective effects that also increases neurogenesis, decreases apoptosis and inflammation, modulates the hypothalamic-pituitary-adrenal axis, and markedly increases GABA(A) receptor responses. Pregnenolone administration elevates pregnenolone sulfate, a neurosteroid that positively modulates NMDA receptors. |
| 研究领域 | |
| 研究领域 | Neuroscience Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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