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| 品牌 | absin | CAS | 51460-26-5 |
|---|---|---|---|
| 分子式 | C10H17N4NaO8S | 纯度 | 97% |
| 分子量 | 376.32 | 货号 | abs47027342 |
| 规格 | 2mg | 供货周期 | 现货 |
| 主要用途 | use in the treatment of hemorrhoids | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Carbazochrome sodium sulfonate 51460-26-5
| 产品描述 | |
| 描述 | Carbazochrome sodium sulfonate (AC-17) is an antihemorrhagic for use in the treatment of hemorrhoids |
| 纯度 | 97% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 可溶性/溶解性 | Soluble in DMSO > 10 mM |
| 生物活性 | |
| In vitro(体外研究) | Carbazochrome (0.1–1 M) reverses the barrier dysfunction induced by tryptase, thrombin and bradykinin without affecting the endothelial permeability enhanced by Ca(2+) ionophores such as ionomycin and A23187 or phorbol 12-myristate 13-acetate. Carbazochrome reverses the tryptase-induced formation of actin stress fibres and disruption of VE-cadherin in the monolayers of cultured porcine aortic endothelial cells (PAECs). Carbazochrome (0.1-10 M) reduces concentration-dependently the enhancement of inositol triphosphate formation from myo-inositol induced by bradykinin and thrombin. Carbazochrome significantly blocks the hyperpermeability induced in cultured bovine endothelial cells by tryptase, thrombin and proteinase-activated receptor-2 agonist peptide (SLIGKV-NH(2)). Carbazochrome significantly decreases the t-PA:Ag in the culture medium of human umbilical vein endothelial cells (HUVEC), while it has no significant effect on the PAI-1:Ag. |
| In vivo(体内研究) | Carbazochrome (10 mg/kg) reverses the ioxaglate-induced vascular hyperpermeability in a dose-dependent manner in rats. Carbazochrome (10 mg/kg) significantly inhibits the decrease in arterial pO(2). |
| 参考文献 | |
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| 研究领域 | |
| 研究领域 | Cardiovascular Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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