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| 品牌 | absin | CAS | 196309-76-9 |
|---|---|---|---|
| 分子式 | C13H15NO2S | 纯度 | ＞98% |
| 分子量 | 249.33 | 货号 | abs812008 |
| 规格 | 10mg | 供货周期 | 现货 |
| 主要用途 | is an irreversible inhibitor of TNFα-ind | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
BAY11-7085 196309-76-9
| 产品描述 | |
| 描述 | BAY 11-7085 is an irreversible inhibitor of TNFα-induced IκBα phosphorylation with IC50 of 10 μM. |
| 纯度 | ＞98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | BAY 11-7085；BAY-11-7085；BAY 11-7083 |
| 外观 | white solid |
| 可溶性/溶解性 | DMSO : 24.9 mg/mL (100 mM) Ethanol : 24.9 mg/mL (100 mM) |
| 生物活性 | |
| 靶点 | IκBα phosphorylation |
| In vitro(体外研究) | BAY 11-7085 inhibits TNFα-induced expression of adhesion molecules E-selectin, VCAM-1, and ICAM-1 by inhibition of NF-κB without detectable cytotoxicity at 10 μM in HUVEC cells. BAY 11-7085 enhances the inhibition of NFkappaB activity by paclitaxel and decreases the viability of cells treated with paclitaxel. Besides, combination of Bay11-7085 and LY294002 leads to synergistic apoptotic effect in PEL cells. |
| In vivo(体内研究) | BAY 11-7085 inhibits the meningitis-associated increase in NF-κB activity, and results in an improvement of the clinical status of infected rats and a marked attenuation of meningitis-associated CNS complications and meningeal inflammation. BAY 11-7085 increases the efficacy of paclitaxel-induced inhibition of intraabdominal dissemination and production of ascites in athymic nude mice bearing Caov-3 cells. |
| 研究领域 | |
| 研究领域 | Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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