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| 品牌 | absin | CAS | 121917-57-5 |
|---|---|---|---|
| 分子式 | C20H19NO4 | 纯度 | ＞98% |
| 分子量 | 337.37 | 货号 | abs810778 |
| 规格 | 10mg | 供货周期 | 现货 |
| 主要用途 | is the enantiomer of (+)-MK-801 | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
（-）MK-801 maleate 121917-57-5
| 产品描述 | |
| 描述 | (-)-MK 801 Maleate is the enantiomer of (+)-MK-801; (+)-MK-801 is a highly potent and selective non-competitive NMDA glutamate receptor antagonist . |
| 纯度 | >98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | MK 801; MK801; C13737 |
| 外观 | Powder |
| 可溶性/溶解性 | DMSO：67 mg/mL (198.59 mM) Ethanol：7 mg/mL (20.74 mM) |
| 生物活性 | |
| 靶点 | NMDA receptor |
| In vitro(体外研究) | Neurophysiological studies in vitro, using a rat cortical-slice preparation, demonstrates a potent, selective, and noncompetitive antagonistic action of dizocilpine on depolarizing responses to N-Me-D-Asp but not to kainate or quisqualate. The potencies of phencyclidine, ketamine, SKF 10047, and the enantiomers of dizocilpine as N-Me-D-Asp antagonists correlate closely (r = 0.99) with their potencies as inhibitors of dizocilpine binding. This suggests that the dizocilpine binding sites are associated with N-Me-D-Asp receptors and provides an explanation for the mechanism of action of dizocilpine as an anticonvulsant. |
| In vivo(体内研究) | All the control rats have severe permanent neurological deficits after ischemic spinal cord injury (ISCI), whereas the dizocilpine–treated rats have statistically (P |
| 参考文献 | |
| 参考文献 | [1] Wong EH et al., Proc Natl Acad Sci U S A, 1986, 83(18), 7104-7108. [2] Wise-Faberowski L et al., J Neurosurg Anesthesiol, 2006, 18(4), 240-246. [3] Kocaeli H et al., Surg Neurol, 2005, 64 Suppl 2, S22-S26. |
| 研究领域 | |
| 研究领域 | Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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