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| 品牌 | absin | CAS | 603288-22-8 |
|---|---|---|---|
| 分子式 | C28H25FN6O3 | 纯度 | ＞98% |
| 分子量 | 512.53 | 货号 | abs810372 |
| 规格 | 5mg | 供货周期 | 现货 |
| 主要用途 | is a potent inhibitor of glycogen syntha | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
LY2090314 603288-22-8
| 产品描述 | |
| 描述 | LY2090314 is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with IC50s of 1.5 nM and 0.9 nM for GSK-3α and GSK-3β respectively. |
| 纯度 | ＞98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | LY 2090314；LY-2090314 |
| 外观 | yellow to orange powder |
| 可溶性/溶解性 | DMSO : 93 mg/mL (181.5 mM) Ethanol : 2 mg/mL warmed (3.9 mM) |
| 生物活性 | |
| 靶点 | GSK-3β；GSK-3α |
| In vitro(体外研究) | LY2090314 selectively inhibits the activity of GSK-3 by interrupting ATP binding. LY2090314 is able to stabilize β-catenin. LY2090314 shows limited efficacy as monotherapy. LY3090314 enhances the efficacy of cisplatin and carboplatin in solid tumor cancer cell lines in vitro. |
| In vivo(体内研究) | LY2090314 enhances the efficacy of cisplatin and carboplatin in solid tumor cancer xenografts. |
| 研究领域 | |
| 研究领域 | Stem CellsSignaling Pathways Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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