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Product Category详细介绍
| 品牌 | absin | CAS | 1253952-02-1 |
|---|---|---|---|
| 分子式 | C28H29Cl2N3O3 | 纯度 | ≥98% |
| 分子量 | 526.45 | 货号 | abs818493 |
| 规格 | 2mg | 供货周期 | 现货 |
| 主要用途 | 是ROCK抑制剂 | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
AR-13324 hydrochloride 1253952-02-1
| 产品描述 | |
| 描述 | AR-13324是ROCK抑制剂，Ki值为0.2-10.3 nM。 |
| 纯度 | ≥98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 奈他地尔;Netarsudil hydrochloride；Netarsudil (AR-13324) 2HCl |
| 外观 | White to off white powder |
| 可溶性/溶解性 | DMSO ：20 mg/mL (37.99 mM) |
| 生物活性 | |
| 靶点 | ROCK |
| In vitro(体外研究) | Previous study showed that at the cellular level, netarsudil had been shown to be able to induce loss of actin stress fibers, cell shape changes, loss of focal adhesions, as well as changes in extracellular matrix composition of TM cells. |
| In vivo(体内研究) | Animal efficacy study found that the topical treatment of netarsudil was able to affect both proximal (trabecular meshwork and Schlemm's Canal) and distal portions (intrascleral vessels) of the mouse conventional outflow tract. |
| 研究领域 | |
| 研究领域 | Stem CellsSignaling Pathways Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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