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| 品牌 | absin | CAS | 109511-58-2 |
|---|---|---|---|
| 分子式 | C18H16N6S2 | 纯度 | >98% |
| 分子量 | 380.48 | 货号 | abs810003 |
| 规格 | 5mg;10mg;25mg;50mg;100mg | 供货周期 | 现货 |
| 主要用途 | is a selective MAP Kinase Kinase inhibit | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
| 产品描述 | |
| 描述 | U0126 is a selective MAP Kinase Kinase inhibitor, displaying a preference for MEK-1 (IC50 = 72 nM) and MEK-2 (IC50 58nM). It is known that U-0126 binds to MEK in a noncompetitive manner compared to ATP. Studies suggest that U-0126 antagonizes the transcription of AP-1, via the inhibition of MEK. In addition, U-0126 has been observed to inhibit promoters containing an AP-1 response element, while in contrast having no effect on promoters that lack an AP-1 response group. U-0126 is also useful in neuronal studies in mice since it displays inhibitory effects against oxidative stress. U-0126 is an activator of PGC-1, mtTFA and nuclear respiratory factor. |
| 纯度 | >98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | U0126；U 0126 |
| 外观 | Lyophilized powder |
| 可溶性/溶解性 | Soluble in DMSO at 200 mg/mL |
| 研究领域 | |
| 研究领域 | CancerSignal transductionProtein phosphorylationSerine/threonine kinasesMAPK pathway Signal TransductionProtein PhosphorylationSer / Thr KinasesMAPK Pathway Signal TransductionProtein PhosphorylationTyrosine KinasesOther Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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