全国服务咨询热线：
18438616290
18438616290
简要描述：Quisinostat (JNJ-26481585) 2HCl 875320-31-3Quisinostat (JNJ-26481585) 2HCl is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM in a cell-free assay
产品型号：abs810796厂商性质：生产厂家更新时间：2026-02-06访 问 量：1129产品分类
Product Category详细介绍
| 品牌 | absin | CAS | 875320-31-3 |
|---|---|---|---|
| 分子式 | C21H28Cl2N6O2 | 纯度 | ＞98% |
| 分子量 | 467.39 | 货号 | abs810796 |
| 规格 | 5mg | 供货周期 | 现货 |
| 主要用途 | is a novel second-generation HDAC inhibi | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Quisinostat (JNJ-26481585) 2HCl 875320-31-3
| 产品描述 | |
| 描述 | Quisinostat (JNJ-26481585) 2HCl is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM in a cell-free assay, modest potent to HDACs 2, 4, 10, and 11. |
| 纯度 | >98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | JNJ26481585,JNJ 26481585 |
| 外观 | Powder |
| 可溶性/溶解性 | DMSO Solubility: 79 mg/mL (169.02 mM) |
| 生物活性 | |
| 靶点 | HDAC1 ,HDAC2 ,HDAC11 ,HDAC10 ,HDAC4 |
| In vitro(体外研究) | JNJ-26481585 exhibits broad spectrum antiproliferative activity in solid and hematologic cancer cell lines, such as all lung, breast, colon, prostate, brain, and ovarian tumor cell lines, with IC50 ranging from 3.1-246 nM, which is more potent than vorinostat, R306465, panobinostat, CRA-24781, or mocetinostat in various human cancer cell lines tested. A recent study shows that JNJ-26481585 promotes myeloma cell death at low nanomolar concentrations by resulting in Mcl-1 depletion and Hsp72 induction. |
| In vivo(体内研究) | In an HDAC1-responsive A2780 ovarian tumor screening model, JNJ-26481585 dosing at its maximal tolerated dose (10 mg/kg i.p. and 40 mg/kg p.o.) for 3 days leads to an HDAC1-regulated fluorescence , which predicts tumor growth inhibition. Furthermore, JNJ-26481585 also shows more potent inhibitory effects on the growth of C170HM2 colorectal liver metastases than 5-fluorouracil/Leucovorin. |
| 研究领域 | |
| 研究领域 | CardiovascularHeartHypertrophyOther EpigeneticsChromatin Modifying EnzymesAcetylation EpigeneticsChromatin Modifying EnzymesAcetylationHDACsClass I Stem CellsSignaling PathwaysWntHDACs Drug DiscoverySmall Molecule DrugLead Compound Discovery |
产品咨询
地址：上海市浦东新区新浩路58号申江科创园18栋
邮箱：lanwu@univ-bio.com
传真：