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| 品牌 | absin | CAS | 852475-26-4 |
|---|---|---|---|
| 分子式 | C17H15FN2O3 | 纯度 | ＞98% |
| 分子量 | 314.31 | 货号 | abs810329 |
| 规格 | 5mg | 供货周期 | 现货 |
| 主要用途 | is a class II (IIa) HDAC inhibitor selec | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
MC1568 852475-26-4
| 产品描述 | |
| 描述 | MC1568 is a class II (IIa) HDAC inhibitor selective for HDAC4 and HDAC6. |
| 纯度 | ＞98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | MC 1568；MC-1568 |
| 外观 | orange powder |
| 可溶性/溶解性 | DMSO 13 mg/mL (41.36 mM) |
| 生物活性 | |
| 靶点 | HD1-A (Maize) ,HD1-B (Maize) |
| In vitro(体外研究) | MC1568 is a selective class II (IIa) histone deacetylas (HDAC II) inhibitor with IC50 of 220 nM and 176-fold class II selectivity (against class I). In human breast cancer ZR-75.1 cell lysates, MC1568 (5 μM) shows no inhibitory activity against HDAC1 but is able to inhibit HDAC4. In MCF-7 cells, MC1568 (20 μM) increases the accumulation of acetylated H3 and H4 histones, as well as the levels of acetyl-tubulin, which indicates a inhibitory effect of MC1568 on HDAC6. In C2C12 cells, MC1568 (5 μM) arrests myogenesis by decreasing myocyte enhancer factor 2D (MEF2D) expression, stabilizing the HDAC4-HDAC3-MEF2D complex, and by inhibiting differentiation-induced MEF2D acetylation. MC1568 (5 or 10 μM) interferes with the RAR- and PPARγ-mediated differentiation-inducing signaling pathways. In F9 cells, MC1568 specifically blocks endodermal differentiation despite not affecting retinoic acid-induced maturation of promyelocytic NB4 cells. In 3T3-L1 cells, MC1568 attenuates PPARγ-induced adipogenesis. |
| In vivo(体内研究) | In mice, MC1568 (50 mg/kg) shows an apparent tissue-selective HDAC inhibition. In skeletal muscle and heart, MC1568 inhibits the activity of HDAC4 and HDAC5 without affecting HDAC3 activity, thereby leaving MEF2-HDAC complexes in a repressed state. In reporting PPRE-Luc mice, MC1568 (50 mg/kg) impairs PPARγ signaling mostly in the heart and adipose tissues. In a recent study of pancreatic explants, MC1568 enhances expression of Pax4, a key factor required for proper β-and δ-cell differentiation and amplifies endocrine β- and δ-cells. |
| 研究领域 | |
| 研究领域 | CancerCancer Metabolism CancerTumor biomarkers Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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