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| 品牌 | absin | CAS | 865854-05-3 |
|---|---|---|---|
| 分子式 | C19H14N2O2S | 纯度 | ＞98% |
| 分子量 | 334.39 | 货号 | abs810147 |
| 规格 | 5mg | 供货周期 | 现货 |
| 主要用途 | is an irreversible | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Tideglusib 865854-05-3
| 产品描述 | |
| 描述 | Tideglusib(NP-031112) is an irreversible, non ATP-competitive GSK-3β inhibitor with IC50 of 60 nM. |
| 纯度 | >98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | NP-12; NP031112; NP 031112; NP-031112 |
| 外观 | Powder |
| 可溶性/溶解性 | DMSO : 12.5 mg/mL (37.38 mM; Need ultrasonic and warming) |
| 生物活性 | |
| 靶点 | GSK-3β |
| In vitro(体外研究) | Tideglusib irreversibly inhibits GSK-3, reduces tau phosphorylation, and prevents apoptotic death in human neuroblastoma cells and murineprimary neurons. Tideglusib (2.5 μM) inhibits glutamate-induced glial activation as evidenced by decreased TNF-α and COX-2 expression in rat primary astrocyte or microglial cultures. Tideglusib (2.5 μM) also exerts a potent neuroprotective effect on cortical neurons from glutamate-induced excitotoxicity as evidenced by significant reduction in the number of Annexin-V-positive cells in rat primary astrocyte or microglial cultures. |
| In vivo(体内研究) | Tideglusib (50 mg/kg) injected into the adult male Wistar rats hippocampus dramatically reduces kainic acid-induced inflammation and has a neuroprotective effect in the damaged areas of the hippocampus. Tideglusib (200 mg/kg, oral) results in lower levels of tau phosphorylation, decreased amyloid deposition and plaque-associated astrocytic proliferation, protection of neurons in the entorhinal cortex and CA1 hippocampal subfield against cell death, and prevention of memory deficits in APP/tau double transgenic mice. |
| 研究领域 | |
| 研究领域 | Stem CellsSignaling Pathways Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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