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| 品牌 | absin | CAS | N/A |
|---|---|---|---|
| 分子式 | C108H206N52O24 | 纯度 | 98% |
| 分子量 | 2617.13 | 货号 | abs814326 |
| 规格 | 10mg | 供货周期 | 现货 |
| 主要用途 | is a cell-penetrating peptide, designed | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
| 产品描述 | |
| 描述 | ReACp53 is a cell-penetrating peptide, designed to inhibit p53 amyloid formation, resues p53 function in cancer cell lines and in organoids derived from high-grade serous ovarian carcinomas (HGSOC). |
| 来源 | Synthetic |
| 序列 | H-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Pro-Ile-Leu-Thr-Arg-Ile-Thr-Leu-Glu-OH |
| 纯度 | 98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 注意事项 | 该产品以TFA盐的形式提供 |
| 基本信息 | |
| 别名 | RRRRRRRRRRPILTRITLE |
| 外观 | White to off-white Powder |
| 可溶性/溶解性 | DMSO ：10 mg/mL (3.82 mM) Water ：100 mg/mL (38.21 mM) |
| 生物活性 | |
| 靶点 | p53 amyloid formation |
| In vitro(体外研究) | ReACp53 rescues p53 transcription of target genes and restores apoptosis. Rescued p53 behaves similarly to its wild-type counterpart in regulating target genes, reducing cell proliferation and increasing cell death. |
| In vivo(体内研究) | ReACp53 halts progression and shrinks tumors bearing aggregation-prone p53. |
| 研究领域 | |
| 研究领域 | CancerCell cycleCell cycle inhibitorsp53 pathway CancerOncoproteins/suppressorsTumor suppressorsp53 pathway ApoptosisIntracellularp53 Pathway Cell CycleCell Cycle Inhibitorsp53 EpigeneticsCell cycleCell Cycle Inhibitorsp53 EpigeneticsDNA / RNADNA Damage & RepairDNA Damage Responsep53 EpigeneticsTranscriptionCancer susceptibilityTumor Suppressors NeuroscienceDevelopment NeuroscienceProcesses Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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