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| 品牌 | absin | CAS | 76684-89-4 |
|---|---|---|---|
| 分子式 | C15H26N2O5 | 纯度 | 98% |
| 分子量 | 314.38 | 货号 | abs47028413 |
| 规格 | 10mg | 供货周期 | 现货 |
| 主要用途 | is an irreversible and membrane-permeant | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Loxistatin Acid (E-64C) 76684-89-4
| 产品描述 | |
| 描述 | E-64c, a derivative of E-64, is an irreversible and membrane-permeant cysteine protease inhibitor. |
| 纯度 | 98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | Loxistatin Acid；E-64-C；E 64c；阿洛司他丁酸 |
| 外观 | 白色粉末 |
| 可溶性/溶解性 | DMSO : 58 mg/mL (184.5 mM) Ethanol : 58 mg/mL (184.5 mM) Water : 2 mg/mL (6.36 mM) |
| 生物活性 | |
| 靶点 | cysteine protease |
| In vitro(体外研究) | Loxistatin Acid (E-64C), as a thiol protease inhibitor, inhibits calpain activity in intact platelets. E-64C inhibits β-secretase activity in regulated secretory vesicles of neuronal chromaffin cells, and decrease Aβ production, indicating a therapeutic strategy for Alzheimer's disease. |
| In vivo(体内研究) | In pectoral muscle of dystrophic chickens, Loxistatin Acid (E-64C) normalizes the increased activities of cathepsin B and cathepsin H. E-64C inhibits ischemic degradation of cerebral proteins following occlusion of the middle cerebral artery in rats. |
| 参考文献 | |
| 参考文献 |
| 研究领域 | |
| 研究领域 | Metabolism Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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