(S)-crizotinib 1374356-45-2

简要描述：(S)-crizotinib 1374356-45-2
(S)-crizotinib, the (S)-enantiomer of crizotinib, is a potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM.

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品牌	absin	CAS	1374356-45-2
分子式	C21H22Cl2FN5O	纯度	98%
分子量	450.34	货号	abs47028403
规格	5mg	供货周期	现货
主要用途	is a potent MTH1 (NUDT1) inhibitor with	应用领域	化工,生物产业,农林牧渔,制药/生物制药,综合

(S)-crizotinib 1374356-45-2

产品描述
描述	(S)-crizotinib, the (S)-enantiomer of crizotinib, is a potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM.
纯度	98%
储存/保存方法	Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
可溶性/溶解性	DMSO:42 mg/mL warmed (93.26 mM)
生物活性
靶点	MTH1
In vitro(体外研究)	(S)-crizotinib disrupts nucleotide pool homeostasis via MTH1 inhibition, induces an increase in DNA single-strand breaks, and activates DNA repair in human colon carcinoma cells.
In vivo(体内研究)	(S)-Crizotinib (50 mg/kg, orally, daily) impairs tumor growth in an SW480 colon carcinoma xenograft model.
参考文献
参考文献	1. Huber KV, et al. Nature. 2014 , 508(7495), 222-227.

研究领域
研究领域	EpigeneticsDNA / RNADNA Damage & RepairBase Excision Repair Drug DiscoverySmall Molecule DrugLead Compound Discovery

(S)-crizotinib 1374356-45-2温馨提示：本产品仅作科研实验使用，不支持临床等研究

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