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| 品牌 | absin | CAS | 6483-15-4 |
|---|---|---|---|
| 分子式 | C15H22N2O | 纯度 | 98% |
| 分子量 | 246.35 | 货号 | abs47028381 |
| 规格 | 10mg | 供货周期 | 现货 |
| 主要用途 | a major ingredient of Sophora alopecuroi | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Sophocarpine 6483-15-4
| 产品描述 | |
| 描述 | Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects. |
| 纯度 | 98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 可溶性/溶解性 | DMSO:49 mg/mL (198.9 mM) |
| 生物活性 | |
| In vitro(体外研究) | Sophocarpine exerts anti-cachectic effects by inhibiting TNF-α and IL-6 production in both RAW264.7 cells and murine primary macrophages. Sophocarpine also shows antivirus activity by inhibiting HHV-6 replication in Molt-3 cells. In addition, Sophocarpine is a potent blocker of HERG K+ channels with an IC50 of about 200 mM. |
| In vivo(体内研究) | Administration of 50 mg/kg/d sophocarpine for 5 days from the onset of cachexia does not inhibit the tumor growth but results in attenuation of cachexia symptoms in colon26 adenocarcinoma xenograft BALB/c mice. LD50: Mice 63.94mg/kg (i.v.) |
| 参考文献 | |
| 参考文献 |
| 研究领域 | |
| 研究领域 | Immunology CancerCancer Metabolism CancerTumor immunology MetabolismTypes of disease Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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