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| 品牌 | absin | CAS | 603-50-9 |
|---|---|---|---|
| 分子式 | C22H19NO4 | 纯度 | ＞98% |
| 分子量 | 361.39 | 货号 | abs47028375 |
| 规格 | 50mg | 供货周期 | 现货 |
| 主要用途 | is a stimulant laxative drug | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Bisacodyl 603-50-9
| 产品描述 | |
| 描述 | Bisacodyl (INN) is a stimulant laxative drug that works directly on the colon to produce a bowel movement. |
| 纯度 | ＞98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 比sha可啶 |
| 外观 | 白色或类白色结晶性粉末 |
| 可溶性/溶解性 | DMSO : 67 mg/mL (185.4 mM) |
| 生物活性 | |
| In vitro(体外研究) | Bisacodyl (10 μg/mL) increases mRNA expression level of TNF-α, COX2 and PGE2 in Raw264.7 cells. |
| In vivo(体内研究) | Bisacodyl (20 mg/kg) results in a decrease in AQP3 protein expression and increased mRNA expression level of TNF-α in the colon of rats. Bisacodyl inhibits water absorption in rat jejunum, ileum, and colon, the degree of inhibition is linearly related to the logarithm of the bisacodyl concentration over the range of 0.05 mg to 2.0 mg per 100 mL. Bisacodyl (10 mg/kg, intragastrically) induces a significant decrease in jejunal NOS activity in rats. Bisacodyl (10 mg/kg, intragastrically) increases the distance traveled by the marker in all time periods. Bisacodyl (5.9 mg/kg) decreases significantly jejunal and colonic (Na + K) ATPase activity as compared to saline-treated rats. Bisacodyl (5.9 mg/kg) increases significantly jejunal and colonic PGE2 content and stimulates jejunal and colonic adenyl cyclase activity as compared to those in control rats without affecting cAMP content. Bisacodyl (4.3 mg/kg) coupled with AOM increases the number of crypt per focus, but not the number of tumors in rats. Bisacodyl (43 mg/kg) significantly increases the number of crypt per focus and tumors in rats. |
| 参考文献 | |
| 参考文献 |
| 研究领域 | |
| 研究领域 | Metabolism Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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