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Product Category详细介绍
| 品牌 | absin | CAS | 475473-26-8 |
|---|---|---|---|
| 分子式 | C5H4ClNO5Ru | 纯度 | 98% |
| 分子量 | 294.61 | 货号 | abs47028365 |
| 规格 | 10mg | 供货周期 | 现货 |
| 主要用途 | is a water-soluble carbon monoxide-relea | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
CORM-3 475473-26-8
| 产品描述 | |
| 描述 | CORM-3 is a water-soluble carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity. |
| 纯度 | 98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 可溶性/溶解性 | DMSO:38 mg/mL (128.98 mM) |
| 生物活性 | |
| In vitro(体外研究) | CORM-3 protects against hypoxia-reoxygenation and oxidative stress by promoting CO release in cardiac cells. CORM-3 attenuates the inflammatory response induced by LPS in RAW264.7 murine macrophages. CORM-3 also uncouples mitochondrial respiration via interaction with the phosphate carrier. |
| In vivo(体内研究) | CORM-3 (40 mg/kg i.p.) prolongs the survival of murine cardiac grafts and attenuates organ rejection in CBA mice transplanted with BALB/c hearts. CORM-3 (20 mg/kg i.p.) decreases cellular infiltration, joint inflammation and destruction in a collagen-induced arthritis mouse model. |
| 参考文献 | |
| 参考文献 |
| 研究领域 | |
| 研究领域 | CancerGrowth factorsTNF CardiovascularAtherosclerosisVascular InflammationInflammatory mediators ImmunologyInnate ImmunityMacrophage / Inflamm. NeuroscienceProcesses Signal TransductionSignaling PathwayNuclear SignalingNFkB Pathway Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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