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| 品牌 | absin | CAS | 43229-80-7 |
|---|---|---|---|
| 分子式 | C19H24N2O4.1/2C4H4O4 | 纯度 | 99% |
| 分子量 | 402.4 | 货号 | abs47028352 |
| 规格 | 10mg | 供货周期 | 现货 |
| 主要用途 | is a potent, selective and long-acting | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Formoterol Hemifumarate 43229-80-7
| 产品描述 | |
| 描述 | Formoterol Hemifumarate is a potent, selective and long-acting?β2-adrenoceptor?agonist used in the management of asthma and chronic obstructive pulmonary disease(COPD). |
| 纯度 | 99% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 富ma酸fu莫特罗 |
| 外观 | 白色粉末 |
| 可溶性/溶解性 | DMSO : 74 mg/mL (183.9 mM) |
| 生物活性 | |
| 靶点 | β2-adrenergic receptor |
| In vitro(体外研究) | Formoterol is a potent airway smooth muscle relaxant with high efficacy, and very high affinity and selectivity for the beta 2-adrenoceptor. Formoterol appears to be retained in airway smooth muscle for extended periods since its relaxant effect on human airway smooth muscle is resistant to repeated washing and formoterol displays 'reassertion' of relaxation after washout of a beta-adrenoceptor antagonist. Formoterol has been demonstrated to potently inhibit these cells and processes in experimental test systems. Formoterol, like salbutamol and salmeterol, relaxes isolated preparations of guinea-pig trachea and human bronchus, and inhibits antigen-induced mediator release from human lung fragments in a concentration-related fashion. |
| In vivo(体内研究) | Formoterol causes dose-related inhibition of histamine-induced bronchoconstriction in conscious guinea-pigs. Formoterol inhibits histamine-induced plasma protein extravasation (PPE) in guinea-pig lung, with significant inhibition being observed at 10 mg /mL and 100 mg /mL. Formoterol (100 mg /mL) inhibits PPE in guinea-pig lung for 2-4 hours, a duration of action intermediate between that previously obtained for salbutamol (1 hour) and salmeterol (> 6 hours). Formoterol inhibits neutrophil accumulation (lipopolysaccharide-induced) in guinea-pig lung but at doses greater than those required to inhibit granulocyte-independent PPE (histamine-induced). Formoterol (100 mg /mL) inhibits PAF-induced eosinophil accumulation in guinea-pig lung. |
| 参考文献 | |
| 参考文献 |
| 研究领域 | |
| 研究领域 | Immunology NeuroscienceEndocrine system Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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