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| 品牌 | absin | CAS | 6384-92-5 |
|---|---|---|---|
| 分子式 | C5H9NO4 | 纯度 | 98% |
| 分子量 | 147.13 | 货号 | abs47028348 |
| 规格 | 50mg | 供货周期 | 现货 |
| 主要用途 | is a specific agonist for NMDA | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
NMDA (N-Methyl-D-aspartic acid) 6384-92-5
| 产品描述 | |
| 描述 | NMDA（N-Methyl-D-aspartic acid）is a specific agonist for NMDA receptor mimicking the action of glutamate, the neurotransmitter which normally acts at that receptor. Phase 4. |
| 纯度 | 98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | N-甲基-D-天冬氨酸；N-Methyl-D-aspartic acid |
| 外观 | 白色粉末 |
| 可溶性/溶解性 | water : 14.7 mg/mL (100 mM) |
| 生物活性 | |
| 靶点 | NMDA receptor |
| In vitro(体外研究) | NMDA is an excitatory amino acid neurotransmitter, which only binds to the NMDA receptor without effecting other glutamate receptors (such as those for AMPA and kainate). NMDA specifically binds to the NR2 subunits of NMDA receptor, and then stimulates the open of non-specific cation channel which can allow the passage of Ca2+ and Na+ into the cell and K+ out of the cell. Activation of the NMDA receptor is able to produce the excitatory postsynaptic potential (EPSP), and trigger the increase of intracellular Ca2+ content which may further take participating in various signaling pathways. NMDA receptor plays a key role in a wide range of physiological (e.g. long-term potentiation and neuronal plasticity) and pathological processes (e.g. excitotoxicity and epilepsy). |
| In vivo(体内研究) | NMDA (0.2 nM) shows significant effects on MF, IF, IL, and EL, respectively, decreasing the mount and intromission frequencies, and shortening the intromission and ejaculation latencies. NMDA and AP-5 significantly, respectively, facilitates and inhibits the ejaculatory behavior during the copulation testing 30 min. Bilateral microinjection of NMDA into PVN significantly increases the baseline LSNA, the peaking increment of LSNA occurred within 5 min from the time of NMDA microinjected into PVN. |
| 参考文献 | |
| 参考文献 |
| 研究领域 | |
| 研究领域 | Neuroscience Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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