(R)-Nepicastat HCl 195881-94-8

简要描述：(R)-Nepicastat HCl 195881-94-8
(R)-Nepicastat HCl, the R-enantiomer of Nepicastat HCl, is a potent and selective inhibitor with IC50 of 25.1 nM

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品牌	absin	CAS	195881-94-8
分子式	C14H15F2N3S.HCl	纯度	98%
分子量	331.81	货号	abs47028337
规格	10mg	供货周期	现货
主要用途	is a potent and selective inhibitor with	应用领域	化工,生物产业,农林牧渔,制药/生物制药,综合

(R)-Nepicastat HCl 195881-94-8

产品描述
描述	(R)-Nepicastat HCl, the R-enantiomer of Nepicastat HCl, is a potent and selective inhibitor with IC50 of 25.1 nM and 18.3 nM for bovine and human dopamine-β-hydroxylase, with negligible affinity for twelve other enzymes and thirteen neurotransmitter receptors.
纯度	98%
储存/保存方法	Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
可溶性/溶解性	DMSO:66 mg/mL (198.9 mM)
生物活性
靶点	Human dopamine-beta-hydroxylase,Bovine dopamine-beta-hydroxylase
In vitro(体外研究)	(R)-Nepicastat produces concentration-dependent inhibition of bovine and human dopamine-β-hydroxylase activity in vitro.
In vivo(体内研究)	(R)-Nepicastat (30 mg/kg, p.o.) reduces noradrenaline content, dopamine content and dopamine/noradrenaline ratio in mesenteric artery and left ventricle of spontaneously hypertensive rats (SHRs).
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参考文献

研究领域
研究领域	Drug DiscoverySmall Molecule DrugLead Compound Discovery

(R)-Nepicastat HCl 195881-94-8温馨提示：本产品仅作科研实验使用，不支持临床等研究

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