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| 品牌 | absin | CAS | 910462-43-0 |
|---|---|---|---|
| 分子式 | C23H21N5O3S | 纯度 | 98% |
| 分子量 | 447.51 | 货号 | abs47028310 |
| 规格 | 10mg | 供货周期 | 现货 |
| 主要用途 | is a selective class I HDAC inhibitor | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Domatinostat 910462-43-0
| 产品描述 | |
| 描述 | Domatinostat (4SC-202 free base) is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. It also displays inhibitory activity against Lysine specific demethylase 1 (LSD1). |
| 纯度 | 98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 4SC-202 free base |
| 可溶性/溶解性 | DMSO:89 mg/mL (198.87 mM) |
| 生物活性 | |
| 靶点 | HDAC3 ,HDAC2 ,HDAC1 ,HDAC11 ,HDAC5 |
| In vitro(体外研究) | In HeLa cells, 4SC-202 induces hyperacetylation of histone H3 with EC50 of 1.1 μM. 4SC-202 induces a G2/M cell cycle arrest by interfering with the normal development of the mitotic spindle and causing collapsed spindle apparatus and multiple nucleation centres. In addition, 4SC-202 shows a broad anti-proliferative activity towards human cancer cell lines with a mean IC50 of 0.7 μM. |
| In vivo(体内研究) | In vivo, 4SC-202 has a high oral bioavailability, and shows high metabolic stability and a low plasma clearance. 4SC-202 (120 mg/kg p.o.) shows pronounced and robust anti-tumor activity in both A549 NSCLC xenograft and RKO27 colon carcinoma model. |
| 研究领域 | |
| 研究领域 | CancerCancer MetabolismMetabolic signaling pathwayMetabolism of lipids and lipoproteins CancerOncoproteins/suppressorsTumor suppressorsOther CardiovascularHeartHypertrophyOther EpigeneticsChromatin Modifying EnzymesAcetylation EpigeneticsChromatin Modifying EnzymesAcetylationHDACsClass I MetabolismTypes of diseaseCancer MetabolismPathways and ProcessesMetabolic signaling pathwaysLipid and lipoprotein metabolismLipid metabolism Stem CellsSignaling PathwaysWntHDACs Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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