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| 品牌 | absin | CAS | 1364488-67-4 |
|---|---|---|---|
| 分子式 | C25H27Cl2N3O4 | 纯度 | 98% |
| 分子量 | 504.41 | 货号 | abs47028268 |
| 规格 | 2mg | 供货周期 | 现货 |
| 主要用途 | is a potent p53-MDM2 antagonist | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
YH239-EE 1364488-67-4
| 产品描述 | |
| 描述 | YH239-EE, the ethyl ester of YH239, is a potent p53-MDM2 antagonist and an apoptosis inducer. |
| 纯度 | 98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 可溶性/溶解性 | DMSO:100 mg/mL (198.25 mM) |
| 生物活性 | |
| 靶点 | p53/MDM2 |
| In vitro(体外研究) | YH239-EE inhibits the growth of OCI-AML-3 cells with wild type p53 by inhibiting the p53-MDM2 interaction. YH239-EE induces cell cycle arrest and causes potent cell apoptosis via activation of p53 and downstream targets in four AML cells (OCI-AML-3 and MOLM-13 with wt p53, NB4 with p53 mutation, and HL60 with p53 deletion). |
| 参考文献 | |
| 参考文献 |
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| 研究领域 | |
| 研究领域 | CancerCell cycleCell cycle inhibitorsp53 pathway CancerOncoproteins/suppressorsTumor suppressorsp53 pathway ApoptosisIntracellularp53 Pathway Cell CycleCell Cycle Inhibitorsp53 EpigeneticsCell cycleCell Cycle Inhibitorsp53 EpigeneticsDNA / RNADNA Damage & RepairDNA Damage Responsep53 EpigeneticsTranscriptionCancer susceptibilityTumor Suppressors NeuroscienceDevelopment NeuroscienceProcesses Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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