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| 品牌 | absin | CAS | 792173-99-0 |
|---|---|---|---|
| 分子式 | C17H13N5O2 | 纯度 | 98% |
| 分子量 | 319.32 | 货号 | abs47028266 |
| 规格 | 2mg | 供货周期 | 现货 |
| 主要用途 | is a selective orexin-1 (OX1) receptor a | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
SB-334867 792173-99-0
| 产品描述 | |
| 描述 | SB-334867 is a selective orexin-1 (OX1) receptor antagonist. |
| 纯度 | 98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | SB-334867 free base |
| 外观 | white to beige powder |
| 可溶性/溶解性 | DMSO : 63 mg/mL (197.29 mM) |
| 生物活性 | |
| 靶点 | OX1 receptor |
| In vitro(体外研究) | In CHO-OX1 cells, SB-334867 inhibits the orexin-A (10 nM) and orexin-B (100 nM)-induced calcium responses with pKB of 7.27 and 7.23 respectively, without effect on the UTP (3 microM)-induced calcium response. |
| In vivo(体内研究) | In both male and female rats, SB-334867 (30 mg/kg, i.p.) significantly reduces natural and orexin-A-induced food intake. SB-334867 (2 mg/kg, i.v.) blocks the effects of antipsychotic drugs on dopamine neuronal activity in rats. SB-334867 also inhibits the development of morphine analgesic tolerance in rats. |
| 研究领域 | |
| 研究领域 | Neuroscience NeuroscienceEndocrine system Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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