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Product Category详细介绍
| 品牌 | absin | CAS | 953769-46-5 |
|---|---|---|---|
| 分子式 | C20H22N4O3S | 纯度 | 98% |
| 分子量 | 398.48 | 货号 | abs47028262 |
| 供货周期 | 现货 | 主要用途 | is an orally active |
| 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
BLZ945 953769-46-5
| 产品描述 | |
| 描述 | BLZ945 is an orally active, potent and selective CSF-1R inhibitor with IC50 of 1 nM, >1000-fold selective against its closest receptor tyrosine kinase homologs. |
| 纯度 | 98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | Sotuletinib；BLZ-945 |
| 外观 | White solid |
| 可溶性/溶解性 | DMSO : 79 mg/mL (198.25 mM) |
| 生物活性 | |
| 靶点 | CSF-1R |
| In vitro(体外研究) | In bone marrow-derived macrophages (BMDMs), BLZ945 specifically inhibits CSF-1-dependent proliferation with EC50 of 67nM, and decreases CSF-1R phosphorylation. BLZ945 blocks the reciprocal effects between macrophages and glioma cells on the survival, proliferation and/ or polarization of each other to promote tumorigenesis. |
| In vivo(体内研究) | In glioma-bearing mice, BLZ945 blocks tumor progression and significantly improves survival via CSF-1R inhibition. BLZ945 also inhibits orthotopic tumor growth of patient-derived proneural tumor spheres and cell lines in vivo. BLZ945 (200 mg/kg, p.o.) decreases the growth of malignant cells in both mouse mammary tumor virus-driven polyomavirus middle T antigen (MMTV-PyMT) model of mammary carcinogenesis and keratin 14-expressing human papillomavirus type 16 (K14-HPV-16) transgenic model of cervical carcinogenesis. |
| 研究领域 | |
| 研究领域 | Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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