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| 品牌 | absin | CAS | 1374828-69-9 |
|---|---|---|---|
| 分子式 | C14H16F3N7 | 纯度 | 98% |
| 分子量 | 339.32 | 货号 | abs47028250 |
| 规格 | 2mg | 供货周期 | 现货 |
| 主要用途 | is a highly potent and selective | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
GNE-0877 1374828-69-9
| 产品描述 | |
| 描述 | GNE-0877 is a highly potent and selective leucine-rich repeat kinase 2 (LRRK2) inhibitor with Ki of 0.7 nM. |
| 纯度 | 98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 可溶性/溶解性 | DMSO:67 mg/mL (197.45 mM) |
| 生物活性 | |
| 靶点 | LRRK2 |
| In vitro(体外研究) | GNE-0877 significantly inhibits LRRK2 cellular activity with IC50 of 3 nM, and shows low turnover in human liver microsomes and hepatocytes. Besides, GNE-0877 is also a reversible CYP1A2 inhibitor with IC50 of 0.7 μM. |
| In vivo(体内研究) | In vivo, GNE-0877 shows good oral bioavailability and brain penetration. GNE-0877 inhibits in vivo LRRK2 Ser1292 autophosphorylation in BAC transgenic mice expressing human LRRK2 protein with the G2019S Parkinson’s disease mutation. |
| 参考文献 | |
| 参考文献 |
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| 研究领域 | |
| 研究领域 | NeuroscienceDiseases NeuroscienceNeurology processNeurodegenerative diseaseParkinson's diseaseSynuclein Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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