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| 品牌 | absin | CAS | 1300031-52-0 |
|---|---|---|---|
| 分子式 | C25H23ClN2O3 | 纯度 | 98% |
| 分子量 | 434.91 | 货号 | abs47028247 |
| 规格 | 2mg | 供货周期 | 现货 |
| 主要用途 | is a highly selective inhibitor of BET | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
GSK1324726A (I-BET726) 1300031-52-0
| 产品描述 | |
| 描述 | GSK1324726A (I-BET726) is a highly selective inhibitor of BET family proteins with IC50 of 41 nM, 31 nM, and 22 nM for BRD2, BRD3, and BRD4, respectively. |
| 纯度 | 98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | I-BET726 |
| 可溶性/溶解性 | DMSO :86 mg/mL (197.74 mM) |
| 生物活性 | |
| 靶点 | BRD4；BRD3；BRD2 |
| In vitro(体外研究) | In neuroblastoma cell lines, GSK1324726A inhibits cell growth and induces cytotoxicity. GSK1324726A also modulates expression of genes involved in apoptosis, signaling, and MYC-family pathways, including the direct suppression of BCL2 and MYCN. |
| In vivo(体内研究) | In the mouse SK–N-AS and CHP-212 models, GSK1324726A (15 mg/kg p.o.) results in tumor growth inhibition and down-regulation MYCN and BCL2 expression. In a mouse septic shock model, GSK1324726A (10 mg/kg i.v.) shows potent anti-inflammatory effects, and prevents death of diseased animals. |
| 研究领域 | |
| 研究领域 | CancerOncoproteins/suppressorsTumor suppressorsOther EpigeneticsBromodomains EpigeneticsChromatin Binding ProteinsAcetyl Lysine EpigeneticsTranscriptionBromodomain containing Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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