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| 品牌 | absin | CAS | 357166-30-4 |
|---|---|---|---|
| 分子式 | C20H21N5O6.5/2H2O.2Na | 纯度 | 98% |
| 分子量 | 516.42 | 货号 | abs47028242 |
| 规格 | 2mg | 供货周期 | 现货 |
| 主要用途 | is a novel antifolate and antimetabolite | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Pemetrexed Disodium Hydrate 357166-30-4
| 产品描述 | |
| 描述 | Pemetrexed Disodium Hydrate is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively. |
| 纯度 | 98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 可溶性/溶解性 | DMSO:<1 mg/mL (<1 mM) |
| 生物活性 | |
| 靶点 | TS,DHFR,GARFT |
| In vitro(体外研究) | Pemetrexed disodium shows the antiproliferative activity in CCRF-CEM leukemia, GC3/C1 colon carcinoma, and HCT-8 ileocecal carcinoma cells with IC50 of 25 nM, 34 nM and 220 nM, respectively. A recent study shows that cisplatin plus Pemetrexed combined with SOCS-1 gene delivery shows the antitumor effect by inhibition of cell proliferation, invasiveness, and induction of apoptosis in MPM cells infected with adenovirus-expressing SOCS-1 vector. |
| In vivo(体内研究) | In the human H460 non-small cell lung carcinoma xenograft, Pemetrexed disodium produces a duration-dependent tumor growth delay (TGD). |
| 参考文献 | |
| 参考文献 |
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| 研究领域 | |
| 研究领域 | Signal TransductionMetabolism Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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