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| 品牌 | absin | CAS | 909910-43-6 |
|---|---|---|---|
| 分子式 | C25H19N5S | 纯度 | ≥98% |
| 分子量 | 421.52 | 货号 | abs47028218 |
| 规格 | 5mg | 供货周期 | 现货 |
| 主要用途 | is a selective inhibitor of TGF-β type | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
A-83-01 909910-43-6
| 产品描述 | |
| 描述 | A-83-01 is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 with IC50 values of 12 nM, 45 nM and 7.5 nM, respectively. |
| 纯度 | ≥98% |
| 储存/保存方法 | Store at -20℃ for three years（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 注意事项 | 该产品在溶液状态不稳定，建议您现用现配，即刻使用。 |
| 基本信息 | |
| 别名 | A83-01；A 83-01 |
| 外观 | white to beige powder |
| 可溶性/溶解性 | DMSO : 30 mg/mL (71.17 mM; Need ultrasonic) |
| 生物活性 | |
| 靶点 | ALK4；ALK5；ALK7 |
| In vitro(体外研究) | A-83-01 (4 µM) treatment increases myotube formation, the expression of MyHC and the expression of Myf5 and MyoD in C2C12 cells. Expression of pSmad3 is increased by the addition of TGF-β1, and the effects of TGF-β1 are inhibited in ovarian cancer cells by A-83-01. TGF-β1 increases cell motility, adhesion and invasion, while A-83-01 decreases these behaviors in HM-1 cells. A-83-01 treatment significantly increases these parameters within 24 h that is positively related to pericyte coverage and tumor cell proliferation. Apparent diffusion coefficient (ADC) determined by diffusion-weighed imaging is decreased by A-83-01 treatment, suggesting the decrease of tumor interstitial fluid pressure. |
| In vivo(体内研究) | A-83-01 (50, 150 and 500 μg/mouse, i.p.) significantly improves survival of the mice without body weight or neurobehavioral appearances. A-83-01 (0.5 mg/kg, i.p.) shows a significantly stronger antitumor effect in mice bearing M109 cells. |
| 研究领域 | |
| 研究领域 | CancerCancer MetabolismResponse to hypoxia MetabolismPathways and ProcessesMetabolism processesHypoxia NeuroscienceDevelopment Stem CellsSignaling PathwaysTGF betaSurface Molecules Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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