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| 品牌 | absin | CAS | 19309-14-9 |
|---|---|---|---|
| 分子式 | C16H14O4 | 纯度 | 99% |
| 分子量 | 270.28 | 货号 | abs47028203 |
| 规格 | 5mg | 供货周期 | 现货 |
| 主要用途 | is a chalconoid | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Cardamoni 19309-14-9
| 产品描述 | |
| 描述 | Cardamomin (also known as cardamonin) is a chalconoid that has been isolated from several plants including Alpinia katsumadai and Alpinia conchigera. It has received growing attention from the scientific community due to the expectations toward its benefits to human health. |
| 纯度 | 99% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 可溶性/溶解性 | 10 mM in DMSO |
| 生物活性 | |
| In vitro(体外研究) | Cardamonin inhibits cancer cell growth by inducing G2/M phase cell cycle arrest and apoptosis via accumulation of ROS. Cardamonin has been reported to have anti-inflammatory and anti-tumor activities. Cardamonin inhibits activation of the NF-κB pathway, which in turn triggers ROS accumulation to activate JNK mitogen-activated protein kinase (MAPK). Cardamonin inhibits viability of NPC cells. It induces G2/M phase arrest in CNE-2 cells. Cardamonin-induced accumulation of ROS is mediated through inhibition of the NF-κB pathway. Cardamonin selectively blocks TRPA1 activation while did not interact with TRPV1 nor TRPV4 channel. |
| In vivo(体内研究) | Cardamonin inhibits tumor growth in vivo without serious side effects. |
| 参考文献 | |
| 参考文献 |
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| 研究领域 | |
| 研究领域 | CancerCancer Metabolism Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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