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| 品牌 | absin | CAS | 90-24-4 |
|---|---|---|---|
| 分子式 | C10H12O4 | 纯度 | 98% |
| 分子量 | 196.20 | 货号 | abs47028199 |
| 规格 | 10mg | 供货周期 | 现货 |
| 主要用途 | have antispasmodic activity. | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Xanthoxyline 90-24-4
| 产品描述 | |
| 描述 | Derivatives of xanthoxyline have antispasmodic activity. |
| 纯度 | 98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 2-羟基-4,6-二甲氧基苯乙酮 |
| 外观 | White to cream powder |
| 可溶性/溶解性 | 10 mM in DMSO |
| 生物活性 | |
| In vitro(体外研究) | Xanthoxylin (RCX) exhibits potent cytotoxicity in a panel of different cancer cells. It presents IC50 values of 1.6 and 26.0 μM for the HCT116 and ACP-03 cancer cell lines, respectively. Xanthoxylin causes apoptosis in a time- and concentration-dependent manner and induces mitochondrial depolarization in HepG2 cells. It induces DNA intercalation, inhibited DNA synthesis and triggered the caspase-mediated apoptosis pathway in HepG2 cells, as observed by cell shrinkage, internucleosomal DNA fragmentation, externalization of phosphatidylserine, loss of mitochondrial transmembrane potential and activation of caspase-3, -8 and -9. Xanthoxylin increases melanin production, number of dendrites, tyrosinase, and microphthalmia-associated transcription factor (MITF) expression in cultured B16F10 cells. |
| In vivo(体内研究) | Xanthoxylin presents a potent in vivo antitumor effect in C.B-17 SCID mice engrafted with HepG2 cells. |
| 参考文献 | |
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| 研究领域 | |
| 研究领域 | MetabolismTypes of disease Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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