Curcumol 4871-97-0

简要描述：Curcumol 4871-97-0
Curcumol is a pure monomer isolated from Rhizoma Curcumaeis with antitumor activities. Extracted from Curcuma zedoaria(Berg.)

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详细介绍

品牌	absin	CAS	4871-97-0
分子式	C15H24O2	纯度	98%
分子量	236.35	货号	abs47028170
规格	10mg	供货周期	现货
主要用途	is a pure monomer isolated from Rhizoma	应用领域	化工,生物产业,农林牧渔,制药/生物制药,综合

Curcumol 4871-97-0

产品描述
描述	Curcumol is a pure monomer isolated from Rhizoma Curcumaeis with antitumor activities. Extracted from Curcuma zedoaria(Berg.)Rose;Store the product in sealed,cool and dry condition
纯度	98%
储存/保存方法	Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
可溶性/溶解性	10 mM in DMSO
生物活性
靶点	JAK
In vitro(体外研究)	Curcumol induced cell death in human lung adenocarcinoma (ASTC-a-1) cells by inducing G(2)/M phase arrest, nuclear fragmentation, phosphatidylserine externalization and a rapid translocation of Bax from cytosol into mitochondria. While, caspases are not involved in Curcumol-induced apoptosis. Curcumol also benefits rheumatoid arthritis treatment through suppressing the fibroblast-like synoviocytes (FLS) proliferation and DNA synthesis. It attenuates PDGF-BB-induced Jak2 phosphorylation and downregulates STAT1 and STAT3 DNA-binding activities.
参考文献
参考文献	1. Zhang W, et al. Med Oncol, 2011, 28(1), 307-314. 2. Wang H, et al. Evid Based Complement Alternat Med, 2012, 2012, 746426.

研究领域
研究领域	Drug DiscoverySmall Molecule DrugLead Compound Discovery

Curcumol 4871-97-0温馨提示：本产品仅作科研实验使用，不支持临床等研究

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