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| 品牌 | absin | CAS | 477-43-0 |
|---|---|---|---|
| 分子式 | C15H18O2 | 纯度 | ＞98% |
| 分子量 | 230.3 | 货号 | abs47028165 |
| 规格 | 5mg | 供货周期 | 现货 |
| 主要用途 | shows anti-inflammatory, anti-ulcer | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Dehydrocostus Lactone 477-43-0
| 产品描述 | |
| 描述 | Dehydrocostus shows anti-inflammatory, anti-ulcer, immunomodulatory and anti-tumor properties. |
| 纯度 | ＞98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 去氢木香内酯 |
| 外观 | 白色结晶性粉末 |
| 可溶性/溶解性 | DMSO : ≥ 62.5 mg/mL (271.39 mM) |
| 生物活性 | |
| 靶点 | IKKβ ,COX2 |
| In vitro(体外研究) | Dehydrocostus lactone can inhibit PGE2 synthesis in vitro. It significantly decreases the expression of COX-2, but not that of COX-1. After treatment with DHE, the glioblastoma (U118, U251 or U87) cells are significantly inhibited in their viability, proliferation and migration. At the meantime, DHE also induces mitochondria-mediated apoptosis by promoting the release of cytochrome c into cytosol, which activating caspase signaling pathway. DHE significantly suppresses COX-2 expression by inhibiting the phosphorylation of IKKβ via targeting the ATP-binding site, thereby abrogating NF-κB binding and p300 recruitment to COX-2 promoter. DHE suppresses clonogenic and migratory ability of glioblastoma cells and induces apoptosis through mitochondrial pathway. |
| In vivo(体内研究) | Dehydrocostus lactone suppresses the growth of colorecral cancer xenografts transplanted by colon cancer cell line colo205 in athymic mice. The inhibition effect is dose dependent. DHE can cross blood-brain barrier (BBB). Treatment with DHE markedly inhibits neoplastic weight and volume without the notable adverse effects in the xenograft nude mice model, and these effects may be mediated through inhibition of the IKKβ/NF-κB/COX-2 signaling pathway. |
| 参考文献 | |
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| 研究领域 | |
| 研究领域 | Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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