全国服务咨询热线：
18438616290
18438616290
产品分类
Product Category详细介绍
| 品牌 | absin | CAS | 305350-87-2 |
|---|---|---|---|
| 分子式 | C16H12F3N3S | 纯度 | ＞98% |
| 分子量 | 335.35 | 货号 | abs47028140 |
| 规格 | 5mg | 供货周期 | 现货 |
| 主要用途 | is a selective inhibitor for MEK1/2 | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
SL-327 305350-87-2
| 产品描述 | |
| 描述 | SL-327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/ 0.22 μM, no activity towards Erk1, MKK3, MKK4, c-JUN, PKC, PKA, or CamKII;capable of transport through the blood-brain barrier. |
| 纯度 | ＞98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | SL327；SL 327；Mek-1/Mek-2 Inhibitor |
| 外观 | white solid |
| 可溶性/溶解性 | DMSO : 68 mg/mL (202.77 mM; Need ultrasonic) |
| 生物活性 | |
| 靶点 | MEK1；MEK2,AP-1 |
| In vitro(体外研究) | SL-327 is a water soluble, structural homologue of the specific MKK1/2 inhibitor U0126 with IC50 of 0.18 μM and 0.22 μM for MEK1 and MEK2 respectively. SL-327 has no effect on a variety of other kinases, including PKA, PKC, or CamKII. |
| In vivo(体内研究) | SL-327 (50 mg/kg) crosses the blood-brain barrierand and blocks fear conditioning by inhibiting MAPK/ERK phosphorylation. SL-327 (30 mg/kg) significantly impairs spatial learning in mice. SL-327 (50 mg/kg) blocks cocaine-induced properties. |
| 研究领域 | |
| 研究领域 | Signal TransductionProtein PhosphorylationSer / Thr KinasesMAPK Pathway Signal TransductionProtein PhosphorylationTyrosine KinasesOther Drug DiscoverySmall Molecule DrugLead Compound Discovery |
产品咨询
地址：上海市浦东新区新浩路58号申江科创园18栋
邮箱：lanwu@univ-bio.com
传真：