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| 品牌 | absin | CAS | 17374-26-4 |
|---|---|---|---|
| 分子式 | C6HBr4N3 | 纯度 | ＞98% |
| 分子量 | 434.71 | 货号 | abs47028134 |
| 规格 | 5mg | 供货周期 | 现货 |
| 主要用途 | is a highly selective | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
TBB(NSC 231634) 17374-26-4
| 产品描述 | |
| 描述 | TBB(NSC 231634) is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2)with IC50s of 0.9 and 1.6 μM for rat liver and human recombinant CK2 respectively). |
| 纯度 | ＞98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | NSC 231634；TBB (enzyme inhibitor)；4,5,6,7-四溴-1H-苯并三唑 |
| 外观 | 白色固体 |
| 可溶性/溶解性 | Ethanol : 100 mM DMSO : ≥430 mg/mL |
| 生物活性 | |
| 靶点 | CK2 ,CK1 |
| In vitro(体外研究) | In the presence of 10 μM TBB (and 100 μM ATP) only CK2 was drastically inhibited (s85%) whereas three kinases (phosphorylase kinase, glycogen synthase kinase 3L and cyclin-dependent kinase 2/cyclin A) underwent moderate inhibition, with IC50 values one-two orders of magnitude higher than CK2 (IC50 = 0.9 μM). TBB discriminates between CK2 and CK1, being much more e¡ective with the former. |
| In vivo(体内研究) | The extent of retinal neovascularization in a mouse OIR model is reduced by approximately 60% after treatment with TBB (6 days at 60 mg/kg per day). |
| 参考文献 | |
| 参考文献 |
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| 研究领域 | |
| 研究领域 | CancerOncoproteins/suppressorsOncoproteinsSignal transducers CancerSignal transductionProtein phosphorylationSerine/threonine kinasesOther EpigeneticsChromatin RemodelingPolycomb SilencingOther NeuroscienceProcesses Signal TransductionProtein PhosphorylationSer / Thr KinasesOther Kinases Stem CellsHematopoietic ProgenitorsIntracellular Molecules Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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