Fruquintinib 1194506-26-7

简要描述：Fruquintinib 1194506-26-7
Fruquintinib (HMPL-013) is a small molecule vascular endothelial growth factor receptors inhibitor.

产品咨询联系我们

产品分类

Product Category

查看全部

详细介绍

品牌	absin	CAS	1194506-26-7
分子式	C21H19N3O5	纯度	99%
分子量	393.39	货号	abs47028123
规格	10mg	供货周期	现货
主要用途	is a small molecule vascular endothelial	应用领域	化工,生物产业,农林牧渔,制药/生物制药,综合

Fruquintinib 1194506-26-7

产品描述
描述	Fruquintinib (HMPL-013) is a small molecule vascular endothelial growth factor receptors inhibitor.
纯度	99%
储存/保存方法	Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
外观	white powder
可溶性/溶解性	10 mM in DMSO
生物活性
靶点	VEGFR3 ,VEGFR1 ,VEGFR2
In vitro(体外研究)	In in vitro enzymatic and cellular assays, Fruquintinib inhibits VEGFR family kinases and suppressed VEGF/VEGFR cell signaling in human umbilical vein endothelial cell (HUVEC) and human lymphatic endothial cell (HLEC) with IC50 at low nanomolar level. Few kinases are inhibited other than VEGFRs in a panel of 253 kinases test. Fruquintinib is a highly potent inhibitor of VEGF-induced angiogenesis.
In vivo(体内研究)	Fruquintinib demonstrates favorable pharmacokinetic profile in multiple animal species, oral administration of fruquintinib strongly suppressed VEGF-induced VEGFR2 phosphorylation in the lung tissue in mice. The extent and duration of the inhibition of VEGFR2 phosphorylation correlated well with drug exposures. The strong anti-angiogenic effect resulted in robust anti-tumor efficacy in a number of human tumor xenograft models with good dose response.

研究领域

CancerCancer MetabolismResponse to hypoxia

CancerOncoproteins/suppressorsOncoproteinsGrowth factor receptors

CardiovascularAngiogenesisEndothelial Cell Markers

CardiovascularCardiovascular MarkersCell MarkersEndothelial Cells

MetabolismTypes of diseaseCancer

MetabolismPathways and ProcessesMetabolism processesHypoxia

MicrobiologyInterspecies InteractionHost Virus Interaction

NeuroscienceDevelopment

NeuroscienceProcesses

Signal TransductionProtein PhosphorylationTyrosine KinasesReceptor Tyrosine Kinases

Stem CellsEndothelial ProgenitorsEndothelial Markers

Stem CellsHematopoietic ProgenitorsSurface Molecules

Drug DiscoverySmall Molecule DrugLead Compound Discovery

Fruquintinib 1194506-26-7温馨提示：本产品仅作科研实验使用，不支持临床等研究

产品咨询