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| 品牌 | absin | CAS | 1271738-62-5 |
|---|---|---|---|
| 分子式 | C18H25N5S2 | 纯度 | ＞98% |
| 分子量 | 375.55 | 货号 | abs47028120 |
| 规格 | 2mg | 供货周期 | 现货 |
| 主要用途 | is a potent menin-MLL interaction inhibi | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
MI-2 (Menin-MLL Inhibitor) 1271738-62-5
| 产品描述 | |
| 描述 | MI-2 (Menin-MLL Inhibitor) is a potent menin-MLL interaction inhibitor with IC50 of 446 nM. |
| 纯度 | ＞98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | Menin-MLL inhibitor 2；MI 2；MI2 |
| 外观 | Light yellow to yellow solid |
| 可溶性/溶解性 | DMSO : 70 mg/mL (186.4 mM) Ethanol : 70 mg/mL (186.4 mM) |
| 生物活性 | |
| 靶点 | Menin-MLL interaction |
| In vitro(体外研究) | In HEK293 cells, MI-2 accessed the protein target and effectively inhibits the menin-MLL-AF9 interaction. MI-2 effectively blocks MLL fusion protein-mediated leukemic transformation by downregulating the expression of target genes required for MLL fusion protein oncogenic activity. MI-2 also effectively blocks cell proliferation, and induces cell apoptosis in human MLL leukemia cell lines harboring different MLL translocations. |
| 参考文献 | |
| 参考文献 |
| 研究领域 | |
| 研究领域 | Epigenetics Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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