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| 品牌 | absin | CAS | 57-37-4 |
|---|---|---|---|
| 分子式 | C20H26ClNO3 | 纯度 | ＞98% |
| 分子量 | 363.88 | 货号 | abs47028094 |
| 规格 | 25mg | 供货周期 | 现货 |
| 主要用途 | used in the treatment of depression | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Benactyzine hydrochloride 57-37-4
| 产品描述 | |
| 描述 | Benactyzine hydrochloride is a centrally acting muscarinic antagonist. Benactyzine has been used in the treatment of depression and is used in research to investigate the role of cholinergic systems on behavior. |
| 纯度 | ＞98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 盐酸贝那替嗪；盐酸苯乃嗪；乙胺痉平 |
| 外观 | 白色或类白色结晶性粉末 |
| 可溶性/溶解性 | DMSO : 150 mg/mL (412.22 mM; Need ultrasonic and warming) |
| 生物活性 | |
| 靶点 | mAChR |
| In vitro(体外研究) | Benactyzine hydrochloride and drofenine are widely used anticholinergic drugs which are also competitive inhibitors of BChE with Ki values of 0.010±0.001 and 0.003±0.000 mM, respectively. Results indicate that the inhibition of BChE by Benactyzine hydrochloride is pure or partial competitive. Pure competitive inhibition can be distinguished from partial competitive inhibition by plotting v vs [Benactyzine] at a fixed [BTCh]. |
| In vivo(体内研究) | Benactyzine hydrochloride (1 mg/kg) does not influence the attention response. Benactyzine hydrochloride increases the duration of the exploratory-motor reaction, but slightly diminishes the salivation elicited by acetylcholine. There is no blocking effect of Benactyzine hydrochloride and promazine on the EEG-seizure activity elicited by acetylcholine, and almost no inhibitory effect on emotional reactions. Emotional reactions are blocked by high doses of imipramine and promazine, but not by Benactyzine hydrochloride. The data indicates that imipramine, promazine and Benactyzine hydrochloride influence the autonomic effects of serotonin in different ways. Promazine, and especially Benactyzine hydrochloride, inhibit and shorten the period of salivation elicited by the intra-amygdaloid injection of serotonin. |
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| 研究领域 | |
| 研究领域 | MetabolismTypes of diseaseNeurodegenerative disease MetabolismPathways and ProcessesMetabolic signaling pathwaysDrug metabolism NeuroscienceProcesses NeuroscienceNeurology processNeurodegenerative diseaseAlzheimer's diseaseOther NeuroscienceNeurotransmitterAcetylcholine Signal TransductionMetabolismDrug metabolism Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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