Succimer 304-55-2

Name: Succimer 304-55-2abs47028081
Brand: absin
Price: 497 CNY
Availability: InStock

简要描述：Succimer 304-55-2
Succimer is a Lead Chelator. The mechanism of action of succimer is as a Lead Chelating Activity.

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Succimer 304-55-2

产品描述
描述	Succimer is a Lead Chelator. The mechanism of action of succimer is as a Lead Chelating Activity.
纯度	＞98%
储存/保存方法	Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
基本信息
别名	二巯基丁二酸；Dimercaptosuccinic acid; DMSA
外观	白色结晶性粉末
可溶性/溶解性	DMSO ：36 mg/mL (197.56 mM) Ethanol：3 mg/mL (16.46 mM)
生物活性
In vivo(体内研究)	Succimer is a widely used chelating agent for the treatment of Pb poisoning. Red blood cells (RBCs) from lead exposed animals treated with NAC or Succimer are shown to have significantly higher glutathione (GSH) levels and diminished malondialdehyde (MDA) levels when compare to the lead group. Succimer administration also results in decreased glucose 6-phosphate dehydrogenase (G6PD) activity in RBCs from lead exposed animals. Succimer treatment produces a significant reduction in blood lead levels for both lead exposure conditions: the High Pb-succ group has blood lead levels that are 27% of the blood lead levels of the High Pb group at the end of treatment. Succimer is effective in substantially reducing brain lead, as brain lead levels in the High Pb-succ group are 37% of levels in the High Pb group.
参考文献
参考文献	1. Blanusa M, et al. Curr Med Chem. 2005;12(23):2771-94. 2. Aposhian HV, et al. Toxicology. 1995 Mar 31;97(1-3):23-38.

研究领域
研究领域	Drug DiscoverySmall Molecule DrugLead Compound Discovery

Succimer 304-55-2温馨提示：本产品仅作科研实验使用，不支持临床等研究

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