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| 品牌 | absin | CAS | 269055-15-4 |
|---|---|---|---|
| 分子式 | C20H15BrN6O | 纯度 | ＞98% |
| 分子量 | 435.28 | 货号 | abs47028080 |
| 规格 | 10mg | 供货周期 | 现货 |
| 主要用途 | is a diarylpyrimidine non-nucleoside rev | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Etravirine 269055-15-4
| 产品描述 | |
| 描述 | Etravirine is a diarylpyrimidine non-nucleoside reverse transcriptase inhibitor. Etravirine is designed to be active against HIV isolates with mutations that confer resistance to the two most commonly prescribed first-generation NNRTIs. It can bind the enzyme reverse transcriptase (RT) in multiple conformations, both for native and mutant RT, thereby blocking the enzymatic activity of RT. |
| 纯度 | ＞98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 依曲韦林；R165335；TMC125 |
| 外观 | white to off-white |
| 可溶性/溶解性 | DMSO : 39 mg/mL (89.6 mM) |
| 生物活性 | |
| 靶点 | Reverse transcriptase |
| In vitro(体外研究) | Etravirine (TMC125), is highly active against wild-type HIV-1 with EC50 of 1.4 nM to 4.8 nM and shows some activity against HIV-2 with EC50 of 3.5 μM. TMC125 also inhibits a series of HIV-1 group M subtypes and circulating recombinant forms and a group O virus. |
| In vivo(体内研究) | Etravirine has a high genetic barrier to the development of resistance. In phase IIb trials in treatment-experienced patients, including those infected with virus resistant to NNRTIs and protease inhibitors (PIs), TMC125 is active against HIV resistant to currently available NNRTIs, with a similar tolerability profile to that of the control group. |
| 研究领域 | |
| 研究领域 | MetabolismTypes of disease Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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