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| 品牌 | absin | CAS | 150915-40-5 |
|---|---|---|---|
| 分子式 | C22H39ClN2O6S | 纯度 | ＞98% |
| 分子量 | 495.07 | 货号 | abs47028073 |
| 规格 | 5mg | 供货周期 | 现货 |
| 主要用途 | is a potent non-peptide | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
Tirofiban hydrochloride monohydrate 150915-40-5
| 产品描述 | |
| 描述 | Tirofiban hydrochloride monohydrate is a potent non-peptide, glycoprotein IIb/IIIa (integrins alphaIIbbetaIII) antagonist |
| 纯度 | ＞98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | 盐suan替罗非班水合物 |
| 外观 | 白色至类白色粉末 |
| 可溶性/溶解性 | DMSO : 12 mg/mL (24.24 mM; Need ultrasonic and warming) |
| 生物活性 | |
| 靶点 | GPIIb/IIIa |
| In vitro(体外研究) | Tirofiban (MK-383, Aggrastat) is a nonpeptide derivative of tyrosine that selectively inhibits the GP-IIb/IIIa receptor, with minimal effects on the ɑvβ3 vitronectin receptor. It inhibits platelet aggregation of gel-filtered platelets induced by 10 μM ADP with IC50 of 9 nM, but the IC50 for inhibition of human umbilical vein adhesion to vitronectin, which depends on ɑvβ3 vitronectin receptors, is 62 μmol/L. |
| In vivo(体内研究) | Tirofiban Hydrochloride (10 to 500 mg/kg or 360-min continuous i.v. infusions of 1 to 10 micrograms/kg/min) inhibits platelet aggregation responses to ADP and collagen in canine models. When administered to humans at 0.15μg/kg/min for 4 h, Tirofiban produced a 2.5-fold increase in bleeding time and 97% inhibition of ADP-induced platelet aggregation. |
| 参考文献 | |
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| 研究领域 | |
| 研究领域 | Signal TransductionCytoskeleton / ECMCytoskeleton Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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