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| 品牌 | absin | CAS | 313553-47-8 |
|---|---|---|---|
| 分子式 | C18H16N2OS | 纯度 | 99% |
| 分子量 | 308.4 | 货号 | abs47028062 |
| 规格 | 5mg | 供货周期 | 现货 |
| 主要用途 | is a cell-permeable Hec1 inhibitor | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
INH1 313553-47-8
| 产品描述 | |
| 描述 | INH1 is a cell-permeable Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction. |
| 纯度 | 99% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 可溶性/溶解性 | 200 mM in DMSO and ethanol |
| 生物活性 | |
| 靶点 | Hec1 |
| In vitro(体外研究) | INH1 reduces the association of Hec1 with kinetochore and decreases global Nek2 protein level in cells. INH1 effectively inhibits the proliferation of human breast cancer lines with GI50 of 10-21 μM. Moreover, INH1 also elicits cell killing activity in part through impairing the Hec1/Nek2 pathway for the spindle checkpoint regulation. |
| In vivo(体内研究) | INH1 (100 mg/kg i.p.) inhibits breast tumor growth in mice bearing MDA-MB-468 human breast cancer xenograft. |
| 参考文献 | |
| 参考文献 |
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| 研究领域 | |
| 研究领域 | CancerCell cycleCell division Cell CycleCell Division Cell CycleKinases/PhosphatasesOther Signal TransductionProtein PhosphorylationSer / Thr KinasesOther Kinases Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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