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| 品牌 | absin | CAS | 1021868-92-7 |
|---|---|---|---|
| 分子式 | C23H25NO.HCl | 纯度 | 98% |
| 分子量 | 367.91 | 货号 | abs47028052 |
| 规格 | 5mg | 供货周期 | 现货 |
| 主要用途 | is an JAK1/3 inhibitor | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
ZM 39923 hydrochloride 1021868-92-7
| 产品描述 | |
| 描述 | ZM 39923 hydrochloride is an JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR; also found to be sensitive to transglutaminase. |
| 纯度 | 98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 别名 | ZM 39923 HCl |
| 外观 | powder |
| 可溶性/溶解性 | DMSO ：30 mg/mL (81.54 mM) |
| 生物活性 | |
| 靶点 | TGM2,JAK3,EGFR,JAK1 |
| In vitro(体外研究) | ZM39923 breaks down to form the JAK3 inhibitor ZM449829 which exhibit similar IC50 values. ZM39923 decomposes in neutral buffer to afford potent inhibition of the Janus kinase 3, and could be used as a standard Jak3 inhibitor in assays where breakdown could occur. ZM39923 is reduced by 300-fold in the presence of DTT (10 mM) in inhibiting TGM2. ZM39923 is reversible inhibitors when TGM2 is incubated with inhibitors in the absence of Ca2+. ZM39923 shows significant inhibition of crosslinking activity with IC50 of 25 nM in the absence of DTT and IC50 of 10 μM in the presence of DTT. ZM39923 prevents early death in a Drosophila Melanogaster model of a polyQ repeat disorder called Machado-Joseph Disease. ZM39923 inhibits the generation of AICD-FLAG and both Aβ40 and Aβ42 by purified γ-secretase in a concentration-dependent fashion with an approximate IC50 of 20 μM. ZM39923 decreases photoaffinity-labeled PS1-CTF in the presense of γ-secretase. |
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| 研究领域 | |
| 研究领域 | Cell CycleKinases/PhosphatasesCdks EpigeneticsCell cycleKinases/PhosphatasesCdks ImmunologyImmune System DiseasesAntiviral SignalingHIV-related MicrobiologyProteinHuman ProteinDefensin Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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