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| 品牌 | absin | CAS | 1429651-50-2 |
|---|---|---|---|
| 分子式 | C17H18N2O4 | 纯度 | ＞98% |
| 分子量 | 314.34 | 货号 | abs47028043 |
| 规格 | 5mg | 供货周期 | 现货 |
| 主要用途 | is a potent, selective HDAC6 inhibitor | 应用领域 | 化工,生物产业,农林牧渔,制药/生物制药,综合 |
PHOB 1429651-50-2
| 产品描述 | |
| 描述 | HPOB is a potent, selective HDAC6 inhibitor with IC50 of 56 nM, >30-fold selectivity over other HDACs. |
| 纯度 | ＞98% |
| 储存/保存方法 | Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution. |
| 基本信息 | |
| 外观 | white to beige powder |
| 可溶性/溶解性 | DMSO : 50 mg/mL (159.06 mM; Need ultrasonic) |
| 生物活性 | |
| 靶点 | HDAC6,HDAC3,HDAC8,HDAC1,HDAC10 |
| In vitro(体外研究) | In normal (HFS) and transformed (LNCaP, A549, and U87) cells, HPOB induces acetylation of α-tubulin, however, not histones, and inhibits cell growth, however, not viability. In HFS cells, HPOB enhances transformed cell death induced by etoposide, doxorubicin, or SAHA. HPOB also enhancing etoposide-induced transformed cell death via the apoptotic pathway in transformed cells. |
| In vivo(体内研究) | In mice bearing CWR22 human prostate cancer xenografts, HPOB (300 mg/kg/d i.p.), when in combination with SAHA, causes suppression of the growth of established tumors, while produces no significant suppression when used alone. |
| 参考文献 | |
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| 研究领域 | |
| 研究领域 | EpigeneticsChromatin Modifying EnzymesAcetylation EpigeneticsChromatin Modifying EnzymesAcetylationHDACsClass II / Hda1 Class Stem CellsSignaling PathwaysWntHDACs Drug DiscoverySmall Molecule DrugLead Compound Discovery |
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